Notes: A great seed for Azazel as you get Ludo on the first floor.

Items: Ludovico Technique, Small Rock, Cricket’s Head, Spider Bite Brimstone is in the second floor devil room. Notes: Very powerful seed with great projectile protection from shielded tears. Items: Brimstone, Mutant Spider, Magic Mushroom, Lost Contact Notes: Fun with any character but Tammy’s Head makes Azazel the character of choice in this one. Items: Inner Eye, Mutant Spider, 20/20, Tammy’s Head, Multidimensional Baby Here are the best Binding of Isaac seeds for the PC in the Afterbirth+ DLC. The Best Afterbirth+ Seeds PC Afterbirth+ Seeds Afterbirth Plus PC Seeds It gets good fast and you can tailor it how you like after getting these strong items early on. Notes: This is a good seed if you like multiple tears in one shot. Notes: Brimstone is on the 4th floor and the Brimstone is on the 4th floor’s Devil Room. Items: Mutant Spider, Proptosis, Brimstone. Notes: Very OP run that will leave you with triple Brimstone and homing shots to boot. Items: Inner Eye, Almond Milk, Brimstone, Pentagram, Brain Worm. It’s the run that keeps on giving and continues to get stronger the farther you get.

Notes: Very fun Isaac seed that leads to some interesting synergies, particularly if playing as Azazel. Items: Rocket in a Jar, Goat Head, Dead Cat, Soy Milk, Blood Clot. Find the secret rooms to make the most of the run (the Bible is in a secret room on Depths II).

Items: Ankh, Bible, Tech X, Mutant Spider, Guppy’s Collar, Sausage, Faded Polaroid, Flat File. As of time of writing, Repentance is only available for the PC, so all the Repentance seeds below are only for PC. The Best Binding of Isaac Repentance Seeds Best Repentance SeedsĪs the most recent DLC, it was harder to find a lot of the best Binding of Isaac seeds for Repentance, but there are still plenty to be getting on with.

The Best Binding of Isaac Repentance Seeds.

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